NONO Antikörper (AA 350-400)

Produktnummer ABIN7454648

Dieser Anti-NONO Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von NONO in WB, IP und IHC (fp). Geeignet für Human, Maus und Ratte.

Kurzübersicht für NONO Antikörper (AA 350-400) (ABIN7454648)

Target: NONO (Non-POU Domain Containing, Octamer-Binding (NONO))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NONO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-NONO Antikörper

Bindungsspezifität: AA 350-400

Verwendungszweck: Rabbit anti-NONO Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 350 and 400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu NONO

Target: NONO (Non-POU Domain Containing, Octamer-Binding (NONO))

Andere Bezeichnung: NONO

Hintergrund: Background: Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers.

Gen-ID: 4841

NCBI Accession: NP_031389

UniProt: Q15233