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NONO Antikörper (C-Term)

NONO Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2779028
  • Target Alle NONO Antikörper anzeigen
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Bindungsspezifität
    • 15
    • 12
    • 8
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    C-Term
    Reaktivität
    • 77
    • 37
    • 33
    • 15
    • 11
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen
    Wirt
    • 69
    • 7
    • 2
    Kaninchen
    Klonalität
    • 61
    • 17
    Polyklonal
    Konjugat
    • 38
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NONO Antikörper ist unkonjugiert
    Applikation
    • 60
    • 34
    • 27
    • 16
    • 14
    • 14
    • 14
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    DGTLGLTPPT TERFGQAATM EGIGAIGGTP PAFNRAAPGA EFAPNKRRRY
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NONO. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human NONO
    Top Product
    Discover our top product NONO Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 471 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

  • Target
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Andere Bezeichnung
    NONO (NONO Produkte)
    Synonyme
    NMT55 antikoerper, NRB54 antikoerper, P54 antikoerper, P54NRB antikoerper, nmt55 antikoerper, nrb54 antikoerper, p54nrb antikoerper, xp54nrb antikoerper, AA407051 antikoerper, AV149256 antikoerper, nonA antikoerper, non-POU domain containing octamer binding antikoerper, non-POU domain containing, octamer-binding antikoerper, non-POU domain containing, octamer binding L homeolog antikoerper, non-POU-domain-containing, octamer binding protein antikoerper, NONO antikoerper, Nono antikoerper, nono.L antikoerper
    Hintergrund
    NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
    Alias Symbols: P54, NMT55, NRB54, P54NRB
    Protein Interaction Partner: SFPQ, PTBP1, PRKAA2, PIN1, NONO, FUS, DDX6, C11orf68, PSPC1, HUWE1, LMO4, UBC, SUMO2, STAU1, MDM2, RPA3, RPA2, RPA1, ASB18, WWOX, ASB3, ERG, EED, rev, WBP4, TCERG1, APBB1, PRPF40A, LMNA, CD81, PAN2, CTNNB1, ORC5, MYC, ITGA4, IL7R, FN1, EWSR1, YLPM1, RNF43
    Protein Size: 471
    Molekulargewicht
    52 kDa
    Gen-ID
    4841
    NCBI Accession
    NM_007363, NP_031389
    UniProt
    Q15233
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