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NONO Antikörper (C-Term)

NONO Reaktivität: Human, Hund WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN629889
  • Target Alle NONO Antikörper anzeigen
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Bindungsspezifität
    • 15
    • 12
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    C-Term
    Reaktivität
    • 78
    • 38
    • 34
    • 15
    • 12
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 1
    Human, Hund
    Wirt
    • 70
    • 7
    • 2
    Kaninchen
    Klonalität
    • 62
    • 17
    Polyklonal
    Konjugat
    • 39
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NONO Antikörper ist unkonjugiert
    Applikation
    • 61
    • 35
    • 27
    • 17
    • 14
    • 14
    • 14
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    NONO antibody was raised against the C terminal of NONO
    Aufreinigung
    Purified
    Immunogen
    NONO antibody was raised using the C terminal of NONO corresponding to a region with amino acids DGTLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRAAPGAEFAPNKRRRY
    Top Product
    Discover our top product NONO Primärantikörper
  • Applikationshinweise
    WB: 1.25 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.
    Kommentare

    NONO Blocking Peptide, catalog no. 33R-1969, is also available for use as a blocking control in assays to test for specificity of this NONO antibody

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of NONO antibody in PBS
    Konzentration
    Lot specific
    Buffer
    PBS
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Target
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    Andere Bezeichnung
    NONO (NONO Produkte)
    Synonyme
    NMT55 antikoerper, NRB54 antikoerper, P54 antikoerper, P54NRB antikoerper, nmt55 antikoerper, nrb54 antikoerper, p54nrb antikoerper, xp54nrb antikoerper, AA407051 antikoerper, AV149256 antikoerper, nonA antikoerper, non-POU domain containing octamer binding antikoerper, non-POU domain containing, octamer-binding antikoerper, non-POU domain containing, octamer binding L homeolog antikoerper, non-POU-domain-containing, octamer binding protein antikoerper, NONO antikoerper, Nono antikoerper, nono.L antikoerper
    Hintergrund
    NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
    Molekulargewicht
    52 kDa (MW of target protein)
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