MYBL2 Antikörper (AA 250-300)

Produktnummer ABIN7454416

Der Kaninchen Polyklonal Anti-MYBL2-Antikörper wurde für IP und IHC (fp) validiert. Er ist geeignet, MYBL2 in Proben von Human zu detektieren.

Kurzübersicht für MYBL2 Antikörper (AA 250-300) (ABIN7454416)

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYBL2 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-MYBL2 Antikörper

Bindungsspezifität: AA 250-300

Verwendungszweck: Rabbit anti-B-Myb Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 250 and 300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended. A301-654A has not performed satisfactorily when used for WB of B-Myb in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of B-Myb.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu MYBL2

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Andere Bezeichnung: B-Myb

Hintergrund: Background: B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.

Gen-ID: 4605

NCBI Accession: NP_002457

UniProt: P10244

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Chromatin Binding