MYBL2 Antikörper (N-Term)

Produktnummer ABIN3029533

Produktdetails anti-MYBL2 Antikörper

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYBL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human MYBL2/B-MYB (MSRRTRCEDLDELHYQD) was used as the immunogen for this MYBL2 antibody (100% mouse homology).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the MYBL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MYBL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MYBL2

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Andere Bezeichnung: MYBL2 (MYBL2 Produkte)

Synonyme: MYBL2 antikoerper, bmyb antikoerper, b-myb antikoerper, B-Myb antikoerper, Bmyb antikoerper, B-MYB antikoerper, BMYB antikoerper, myb1 antikoerper, MYB proto-oncogene like 2 antikoerper, v-myb avian myeloblastosis viral oncogene homolog-like 2b antikoerper, myeloblastosis oncogene-like 2 antikoerper, MYB proto-oncogene like 2 S homeolog antikoerper, MYBL2 antikoerper, mybl2 antikoerper, mybl2b antikoerper, Mybl2 antikoerper, mybl2.S antikoerper

Hintergrund: V-MYB avian myeloblastosis viral oncogene homolog-like 2, also called MYB-related gene B-MYB, is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. Barletta et al.(1991) assigned the gene to chromosome Xq13. However, Noben-Trauth et al.(1996) demonstrated that this assignment was an error. Using mouse Mybl2 cDNA clones as probes, they assigned the gene in an interspecific backcross panel to distal mouse chromosome 2. Using human cDNA probes in combination with fluorescence in situ hybridization analysis, they localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders and shows high homology of Synteny to mouse chromosome 2. It has been shown to activate the cell division cycle 2, Cyclin D1, and Insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

UniProt: P10244

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Chromatin Binding