Rekombinanter TWIST1 Antikörper (AA 1-50)

Produktnummer ABIN7453340

Der Kaninchen Monoklonal Anti-TWIST1-Antikörper wurde für WB, IP und ICC validiert. Er ist geeignet, TWIST1 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter TWIST1 Antikörper (AA 1-50) (ABIN7453340)

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TWIST1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: BLR156J

Produktdetails anti-TWIST1 Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-TWIST Recombinant Monoclonal Antibody [BLR156J]

Immunogen: between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Phosphate Buffered Saline (PBS) containing 0.2 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TWIST1

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Andere Bezeichnung: TWIST1

Hintergrund: Background: TWIST1 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. TWIST1 forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. TWIST1 may also regulate neural tube closure, limb development and brown fat metabolism. The TWIST1 gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. [taken from NCBI Entrez Gene (Gene ID: 7291)].

Gen-ID: 7291

NCBI Accession: NP_000465

UniProt: Q15672

Pathways: p53 Signalweg, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity