LAT Antikörper (AA 212-262)
Kurzübersicht für LAT Antikörper (AA 212-262) (ABIN7452825)
Target
Alle LAT Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 212-262
-
Verwendungszweck
- Rabbit anti-LAT Antibody, Affinity Purified
-
Homologie
- Mouse,Rat
-
Aufreinigung
- Affinity Purified
-
Immunogen
- between AA 212 and 262
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 1000 μg/mL
-
Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Haltbarkeit
- 12 months
-
-
- LAT (Linker For Activation of T Cells (LAT))
-
Andere Bezeichnung
- LAT
-
Hintergrund
- Background: LAT is required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. [taken from the Universal Protein Resource (UniProt) O43561].
-
Gen-ID
- 27040
-
UniProt
- O43561
-
Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Target
-