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LAT Antikörper (Linker For Activation of T Cells) (Cytoplasmic Domain) Primary Antibody

LAT Reaktivität: Human FACS, IP, WB Wirt: Maus Monoclonal LAT-01 unconjugated
Pubmed (2)
Produktnummer ABIN302069
$418.97
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target
    LAT
    Bindungsspezifität
    Cytoplasmic Domain
    • 18
    • 17
    • 14
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reaktivität
    Human
    • 128
    • 81
    • 78
    • 1
    Wirt
    Maus
    • 114
    • 8
    • 7
    • 2
    Klonalität
    Monoklonal
    • 124
    • 7
    Konjugat
    Dieser LAT Antikörper ist unkonjugiert
    • 70
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Applikation
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    • 83
    • 47
    • 28
    • 17
    • 12
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    Spezifität
    The antibody LAT-01 reacts with Linker for activation of T cells (LAT), a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.
    Klon
    LAT-01
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, 2011 (PubMed).

    Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, 2005 (PubMed).

  • Target
    LAT
    Andere Bezeichnung
    LAT (LAT Antibody Abstract)
    Synonyme
    LAT, lat, LAT1, pp36, linker for activation of T-cells, linker for activation of T cells, LAT, lat, Lat
    Hintergrund
    LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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