Exonuclease 1 Antikörper (AA 725-775)

Produktnummer ABIN7452756

Dieses Anti-Exonuclease 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Exonuclease 1 in WB und IP. Geeignet für Human.

Kurzübersicht für Exonuclease 1 Antikörper (AA 725-775) (ABIN7452756)

Target: Exonuclease 1 (EXO1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Exonuclease 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Exonuclease 1 Antikörper

Bindungsspezifität: AA 725-775

Verwendungszweck: Rabbit anti-Exonuclease 1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 725 and 775

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 5 - 15 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Exonuclease 1

Target: Exonuclease 1 (EXO1)

Andere Bezeichnung: Exonuclease 1

Hintergrund: Background: Exonuclease 1 is a 5'-3' double-stranded DNA exonuclease which may also possess a cryptic 3'-5' double-stranded DNA exonuclease activity. Exonuclease 1 functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. It also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Exonuclease 1 is required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes and is essential for male and female meiosis [taken from the Universal Protein Resource (UniProt) Q9UQ84].

Gen-ID: 9156

NCBI Accession: NP_006018

UniProt: Q9UQ84

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response