TDP1 Antikörper (AA 75-125)
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- Target Alle TDP1 Antikörper anzeigen
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
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Bindungsspezifität
- AA 75-125
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TDP1 Antikörper ist unkonjugiert
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Applikation
- Immunoprecipitation (IP)
- Verwendungszweck
- Rabbit anti-TDP1 Antibody, Affinity Purified
- Aufreinigung
- Affinity Purified
- Immunogen
- between AA 75 and 125
- Isotyp
- IgG
- Top Product
- Discover our top product TDP1 Primärantikörper
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- Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-TDP1 antibody ABIN7453800.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
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- Target
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Andere Bezeichnung
- TDP1 (TDP1 Produkte)
- Synonyme
- 2810481F14Rik antikoerper, 4921509N21Rik antikoerper, AI838772 antikoerper, AW493413 antikoerper, E430034L06Rik antikoerper, MLZ-501 antikoerper, SCAN1 antikoerper, tdp1 antikoerper, MGC83708 antikoerper, TDP1 antikoerper, F8M21.60 antikoerper, F8M21_60 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA Phosphodiesterase (Tdp1) antikoerper, tyrosyl-DNA phosphodiesterase 1 L homeolog antikoerper, tyrosyl-DNA phosphodiesterase-like protein antikoerper, TDP1 antikoerper, Tc00.1047053511191.10 antikoerper, Tdp1 antikoerper, tdp1.L antikoerper, tdp1 antikoerper, PTRG_11198 antikoerper, MCYG_02121 antikoerper, MGYG_03035 antikoerper
- Hintergrund
- Background: Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3' phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3'-phosphoglycolate termini of double-stranded breaks and a variety of other 3'- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
- Gen-ID
- 55775
- NCBI Accession
- NP_001008744
- UniProt
- Q9NUW8
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