XPO1 Antikörper (AA 375-425)
Kurzübersicht für XPO1 Antikörper (AA 375-425) (ABIN7452299)
Target
Alle XPO1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 375-425
-
Verwendungszweck
- Rabbit anti-CRM1 Antibody, Affinity Purified
-
Aufreinigung
- Affinity Purified
-
Immunogen
- between AA 375 and 425
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-CRM1 antibody ABIN7453427.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 1000 μg/mL
-
Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Haltbarkeit
- 12 months
-
-
- XPO1 (Exportin 1 (XPO1))
-
Andere Bezeichnung
- CRM1
-
Hintergrund
- Background: Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.
-
Gen-ID
- 7514
-
NCBI Accession
- NP_003391
-
UniProt
- O14980
-
Pathways
- M Phase
Target
-