XPO1 Antikörper (C-Term)

Produktnummer ABIN2778849

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-XPO1 Antikörper (ABIN2778849) detektiert spezifisch XPO1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Kaninchen, Schwein und Saccharomyces cerevisiae.

Kurzübersicht für XPO1 Antikörper (C-Term) (ABIN2778849)

Target: XPO1 (Exportin 1 (XPO1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Kaninchen, Schwein, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-XPO1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: XPO1 Antibody - C-terminal region

Sequenz: NKLGGHITAE IPQIFDAVFE CTLNMINKDF EEYPEHRTNF FLLLQAVNSH

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against XPO1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40465-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-XPO1 Antikörper (ABIN2778849)

Kalita, Kapinos, Zheng, Rencurel, Zilman, Lim: "Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage." in: The Journal of cell biology, Vol. 221, Issue 3, (2022) (PubMed).

Details zu XPO1

Target: XPO1 (Exportin 1 (XPO1))

Andere Bezeichnung: XPO1

Hintergrund:

Background Information: XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Exportin 1 (CRM1 homolog, yeast)

Alternative Symbols: emb, CRM1, exp1, CRM-1

Protein Name: Exportin-1

Molekulargewicht: 123 kDa

Gen-ID: 7514

NCBI Accession: NP_003391

UniProt: O14980

Pathways: M Phase