APOA1 Antikörper (HRP)

Produktnummer ABIN7449327

Dieses Anti-APOA1-Antikörper ist ein Ziege Polyklonal-Antikörper zur Detektion von APOA1 in WB und ELISA. Geeignet für Human.

Kurzübersicht für APOA1 Antikörper (HRP) (ABIN7449327)

Target: APOA1 (Apolipoprotein A-I (APOA1))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser APOA1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA

Klon: H03

Produktdetails anti-APOA1 Antikörper (HRP)

Verwendungszweck: Goat anti-Human Apo AI [H03] Antibody HRP Conjugated

Immunogen: Human Apolipoprotein AI

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:1,000 - 1:8,000

ELISA: 1:1,000 - 1:8,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 50 mM PBS, 0.1 M NaCl, and 0.01 % Thiomersal, pH 7.4

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu APOA1

Target: APOA1 (Apolipoprotein A-I (APOA1))

Andere Bezeichnung: ApoAI

Hintergrund: Background: Apo AI comprises approximately 70 % of the protein moiety in HDL. It is a single polypeptide chain consisting of 243 amino acid residues without disulfide bound and with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular weight is reported to be 28 kDa (Brewer et al., 1978). The roles of Apo AI in HDL function include reverse cholesterol transportation, lipid cholesterol binding, lecithin-cholesterol acyl transferase (LCAT) activation, and receptor binding, which is responsible for cholesterol esterification in plasma. Besides participate in cholesterol metabolism, Apo AI and HDL also suppress neutrophil activation, inhibit bacterial endotoxin, induce trypanosomal lysis, and other physiological activities. (Brouillette et al., 2001). Apo AI levels may be inversely related to the risk of coronary disease. In previous research, Apo AI may affect diet-induced inflammation by either directly or indirectly altering lipid rafts. (Cheng et al., 2012)

Gen-ID: 335

NCBI Accession: NP_000030

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism