BRCA1 Antikörper (pSer1524)

Produktnummer ABIN7449280

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BRCA1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BRCA1 Antikörper (pSer1524) (ABIN7449280)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BRCA1 Antikörper

Bindungsspezifität: pSer1524

Verwendungszweck: Rabbit anti-Phospho BRCA1 (S1524) Antibody, Affinity Purified

Homologie: Gorilla,Chimpanzee

Aufreinigung: Affinity Purified

Immunogen: surrounding serine 1524

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:500 - 1:5,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: BRCA1

Hintergrund: Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Gen-ID: 672

NCBI Accession: NP_009225

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus