14-3-3 sigma/SFN Antikörper (AA 198-248)

Produktnummer ABIN7448925

Dieses Anti-14-3-3 sigma/SFN-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von 14-3-3 sigma/SFN in IHC und IF (p). Geeignet für Human.

Kurzübersicht für 14-3-3 sigma/SFN Antikörper (AA 198-248) (ABIN7448925)

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 14-3-3 sigma/SFN Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-14-3-3 sigma/SFN Antikörper

Bindungsspezifität: AA 198-248

Verwendungszweck: Rabbit anti-14-3-3 Sigma IHC Antibody, Affinity Purified

Homologie: Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon,Crab-eating macaque

Aufreinigung: Affinity Purified

Immunogen: Between AA 198 and 248

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu 14-3-3 sigma/SFN

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Andere Bezeichnung: 14-3-3 Sigma

Hintergrund: Background: 14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.

Gen-ID: 2810

NCBI Accession: NP_006133

UniProt: P31947

Pathways: p53 Signalweg, Myometrial Relaxation and Contraction