PTBP1 Antikörper

Produktnummer ABIN7384487

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch PTBP1 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Hamster.

Kurzübersicht für PTBP1 Antikörper (ABIN7384487)

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reaktivität: Human, Maus, Hamster

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PTBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: R01-1G2

Produktdetails anti-PTBP1 Antikörper

Aufreinigung: Affinity Purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:3000 IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PTBP1

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Andere Bezeichnung: PTBP1

Hintergrund: PTBP1,HNRNP-I,HNRNPI,HNRPI,PTB,PTB-1,PTB-T,PTB2,PTB3,PTB4,pPTB,This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Molekulargewicht:

Observed_MW: 57 kDa

Calculated_MW: 57 kDa

Gen-ID: 5725

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation