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Presenilin 1 Antikörper

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch Presenilin 1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7384484

Kurzübersicht für Presenilin 1 Antikörper (ABIN7384484)

Target

Alle Presenilin 1 (PSEN1) Antikörper anzeigen
Presenilin 1 (PSEN1)

Reaktivität

  • 107
  • 81
  • 59
  • 9
  • 9
  • 8
  • 6
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 98
  • 38
  • 2
  • 2
  • 2
  • 1
Kaninchen

Klonalität

  • 133
  • 10
Monoklonal

Konjugat

  • 63
  • 9
  • 9
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Presenilin 1 Antikörper ist unkonjugiert

Applikation

  • 110
  • 57
  • 52
  • 52
  • 40
  • 18
  • 18
  • 17
  • 13
  • 12
  • 9
  • 1
  • 1
Western Blotting (WB)

Klon

R05-4D4
  • Aufreinigung

    Affinity Purified

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    300 μg/mL

    Buffer

    50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    Presenilin 1 (PSEN1)

    Andere Bezeichnung

    Presenilin 1

    Hintergrund

    AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

    Molekulargewicht

    Observed_MW: 20kDa

    Calculated_MW: 53kDa

    Gen-ID

    5663

    UniProt

    P49768

    Pathways

    Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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