Presenilin 1 Antikörper
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- Target Alle Presenilin 1 (PSEN1) Antikörper anzeigen
- Presenilin 1 (PSEN1)
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser Presenilin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity Purified
- Klon
- R05-4D4
- Isotyp
- IgG
- Top Product
- Discover our top product PSEN1 Primärantikörper
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 Reaktivität: Human, Maus WB, IHC (p), IF, FACS Wirt: Kaninchen Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 Reaktivität: Human, Maus, Affe, Rind (Kuh), Schwein, Meerschweinchen, Pferd WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Affe, Schwein, Meerschweinchen, Hund, Fledermaus, Hamster WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (N-Term) antibodyPSEN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Ser45), (Thr41) antibodyPSEN1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 10-80) antibodyPSEN1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:1000-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 300 μg/mL
- Buffer
- 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Presenilin 1 (PSEN1)
- Andere Bezeichnung
- Presenilin 1 (PSEN1 Produkte)
- Hintergrund
- AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- Molekulargewicht
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Observed_MW: 20kDa
Calculated_MW: 53kDa
- Gen-ID
- 5663
- UniProt
- P49768
- Pathways
- Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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