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WWTR1 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch WWTR1 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7271395

Kurzübersicht für WWTR1 Antikörper (C-Term) (ABIN7271395)

Target

Alle WWTR1 Antikörper anzeigen
WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität

  • 34
  • 8
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 29
  • 5
Kaninchen

Klonalität

  • 29
  • 5
Polyklonal

Konjugat

  • 24
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WWTR1 Antikörper ist unkonjugiert

Applikation

  • 27
  • 12
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Bindungsspezifität

    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Verwendungszweck

    TAZ Rabbit pAb

    Sequenz

    LNGGPYHSRE QSTDSGLGLG CYSVPTTPED FLSNVDEMDT GENAGQTPMN INPQQTRFPD FLDCLPGTNV DLGTLESEDL IPLFNDVESA LNKSEPFLTW L

    Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human TAZ (NP_056287.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IF,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

    Andere Bezeichnung

    WWTR1

    Hintergrund

    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1

    Molekulargewicht

    44kDa

    Gen-ID

    25937

    UniProt

    Q9GZV5

    Pathways

    Regulation of Lipid Metabolism by PPARalpha
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