ERBB4 Antikörper

Produktnummer ABIN7271256

Der Kaninchen Monoklonal anti-ERBB4 Antikörper (ABIN7271256) detektiert spezifisch ERBB4 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ERBB4 Antikörper (ABIN7271256)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ERBB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ERBB4 Antikörper

Verwendungszweck: ErbB4/HER4 Rabbit mAb

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human ErbB4/HER4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Andere Bezeichnung: ERBB4

Hintergrund: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4,Cancer,Cell Biology & Developmental Biology,ErbB-HER Signaling Pathway,Growth factors,Growth factors_EGF,Immunology & Inflammation,Kinase,Kinase_Tyrosine kinases,Protein phosphorylation,Signal Transduction,Tumor biomarkers,ERBB4

Molekulargewicht: 160kDa

Gen-ID: 2066

UniProt: Q15303

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung