Topoisomerase II alpha Antikörper (AA 1050-1150)

Produktnummer ABIN7270853

Der Kaninchen Polyklonal Anti-Topoisomerase II alpha-Antikörper wurde für WB validiert. Er ist geeignet, Topoisomerase II alpha in Proben von Human zu detektieren.

Kurzübersicht für Topoisomerase II alpha Antikörper (AA 1050-1150) (ABIN7270853)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Topoisomerase II alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Topoisomerase II alpha Antikörper

Bindungsspezifität: AA 1050-1150

Verwendungszweck: DNA topoisomerase II alpha (TOP2A) Rabbit pAb

Sequenz: NQARFILEKI DGKIIIENKP KKELIKVLIQ RGYDSDPVKA WKEAQQKVPD EEENEESDNE KETEKSDSVT DSGPTFNYLL DMPLWYLTKE KKDELCRLRN E

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human DNA topoisomerase II alpha (DNA topoisomerase II alpha (TOP2A)) (NP_001058.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Andere Bezeichnung: TOP2A

Hintergrund: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.,TOP2A,TOP2,TP2A,Epigenetics & Nuclear Signaling,Cancer,Drug resistance,Topoisomerases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Centrosome,G2/M DNA Damage Checkpoint,TOP2A

Molekulargewicht: 174kDa/177kDa/178kDa/182kDa

Gen-ID: 7153

UniProt: P11388

Pathways: Zellzyklus, Mitotic G1-G1/S Phases