TTC3 Antikörper (AA 1400-1700)

Produktnummer ABIN7270791

Dieses Anti-TTC3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TTC3 in WB. Geeignet für Human.

Kurzübersicht für TTC3 Antikörper (AA 1400-1700) (ABIN7270791)

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TTC3 Antikörper

Bindungsspezifität: AA 1400-1700

Verwendungszweck: TTC3 Rabbit pAb

Sequenz: IASETQILEG SLGISVKSHC STGDAHTVLS ESNRNDEHCG NSNNKCEVIP ESTSAVTNIP HVQMVAIQVS WNIIHQEVNT EPYNPFEERQ GEISRIEKEH QVLQDQLQEV YENYEQIKLK GLEETRDLEE KLKRHLEENK ISKTELDWFL QDLEREIKKW QQEKKEIQER LKSLKKKIKK VSNASEMYTQ KNDGKEKEHE LHLDQSLEIS NTLTNEKMKI EEYIKKGKED YEESHQRAVA AEVSVLENWK ESEVYKLQIM ESQAEAFLKK LGLISRDPAA YPDMESDIRS WELFLSNVTK E

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human TTC3 (NP_003307.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TTC3

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Andere Bezeichnung: TTC3

Hintergrund: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3 in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation.,TTC3,DCRR1,RNF105,TPRDIII,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Neuroscience,TTC3

Molekulargewicht: 194kDa/203kDa/229kDa

Gen-ID: 7267

UniProt: P53804