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TTC3 Antikörper (AA 1400-1700)

This anti-TTC3 antibody (ABIN7270791) is a Rabbit Polyclonal antibody detecting TTC3 in WB. Suitable for Human.
Produktnummer ABIN7270791

Kurzübersicht für TTC3 Antikörper (AA 1400-1700) (ABIN7270791)

Target

Alle TTC3 Antikörper anzeigen
TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Reaktivität

  • 4
  • 4
  • 3
Human

Wirt

  • 5
  • 2
Kaninchen

Klonalität

  • 6
  • 1
Polyklonal

Konjugat

  • 5
  • 1
  • 1
Dieser TTC3 Antikörper ist unkonjugiert

Applikation

  • 4
  • 3
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 3
    • 2
    • 1
    AA 1400-1700

    Verwendungszweck

    TTC3 Rabbit pAb

    Sequenz

    IASETQILEG SLGISVKSHC STGDAHTVLS ESNRNDEHCG NSNNKCEVIP ESTSAVTNIP HVQMVAIQVS WNIIHQEVNT EPYNPFEERQ GEISRIEKEH QVLQDQLQEV YENYEQIKLK GLEETRDLEE KLKRHLEENK ISKTELDWFL QDLEREIKKW QQEKKEIQER LKSLKKKIKK VSNASEMYTQ KNDGKEKEHE LHLDQSLEIS NTLTNEKMKI EEYIKKGKED YEESHQRAVA AEVSVLENWK ESEVYKLQIM ESQAEAFLKK LGLISRDPAA YPDMESDIRS WELFLSNVTK E

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human TTC3 (NP_003307.3).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

    Andere Bezeichnung

    TTC3

    Hintergrund

    E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3 in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation.,TTC3,DCRR1,RNF105,TPRDIII,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Neuroscience,TTC3

    Molekulargewicht

    194kDa/203kDa/229kDa

    Gen-ID

    7267

    UniProt

    P53804
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