TERT Antikörper (C-Term)

Produktnummer ABIN7270762

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TERT in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TERT Antikörper (C-Term) (ABIN7270762)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TERT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TERT Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: TERT Rabbit pAb

Sequenz: NIYKILLLQA YRFHACVLQL PFHQQVWKNP TFFLRVISDT ASLCYSILKA KNAGMSLGAK GAAGPLPSEA VQWLCHQAFL LKLTRHRVTY VPLLGSLRTA QTQLSRKLPG TTLTALEAAA NPALPSDFKT ILD

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human TERT (NP_937983.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Andere Bezeichnung: TERT

Hintergrund: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.,TERT,CMM9,DKCA2,DKCB4,EST2,PFBMFT1,TCS1,TP2,TRT,hEST2,hTRT,Epigenetics & Nuclear Signaling,Cancer,Tumor biomarkers,Cell Biology & Developmental Biology,Stem Cells,Embryonic Stem Cells,TERT

Molekulargewicht: 88kDa/90kDa/120kDa/126kDa

Gen-ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance