TERT Antikörper (pTyr707)

Produktnummer ABIN390002

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-TERT Antikörper wird verwendet zum Nachweis von TERT in Proben von Human. Er wurde validiert für IF und DB.

Kurzübersicht für TERT Antikörper (pTyr707) (ABIN390002)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TERT Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Dot Blot (DB)

Klon: RB16840

Produktdetails anti-TERT Antikörper

Bindungsspezifität: pTyr707

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TERT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y707 of human TERT.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-TERT Antikörper (ABIN390002)

Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: "Microenvironmental regulation of telomerase isoforms in human embryonic stem cells." in: Stem cells and development, Vol. 23, Issue 17, pp. 2046-66, (2014) (PubMed).

Pecec, Voiculetz: "An antibody sandwich method for the radioimmunoassay of human alpha-fetoprotein." in: Immunochemistry, Vol. 11, Issue 12, pp. 771-5, (1975) (PubMed).

Details zu TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Andere Bezeichnung: TERT

Hintergrund: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Molekulargewicht: 126997

Gen-ID: 7015

NCBI Accession: NP_001180305, NP_937983

UniProt: O14746

Pathways: Telomere Maintenance