SIRT1 Antikörper (pSer47)

Produktnummer ABIN7270323

Dieses Anti-SIRT1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von SIRT1 in WB. Geeignet für Human.

Kurzübersicht für SIRT1 Antikörper (pSer47) (ABIN7270323)

Target: SIRT1 (Sirtuin 1 (SIRT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SIRT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SIRT1 Antikörper

Bindungsspezifität: pSer47

Verwendungszweck: Phospho-SIRT1-S47 Rabbit mAb

Kreuzreaktivität: Human, Maus

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding S47 of human SIRT1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SIRT1

Target: SIRT1 (Sirtuin 1 (SIRT1))

Andere Bezeichnung: SIRT1

Hintergrund: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],SIR2, SIR2L1, SIR2alpha,AMPK Signaling Pathway,Apoptosis,Cell Biology & Developmental Biology,Endocrine & Metabolism,Epigenetic writers and erasers of core Histones,Epigenetic writers and erasers of core Histones_Deacetylation,Epigenetics & Nuclear Signaling,Mitochondrial metabolism,SIRT1

Molekulargewicht: 82kDa

Gen-ID: 23411

UniProt: Q96EB6

Pathways: MAPK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling