AMFR Antikörper (AA 85-180)

Produktnummer ABIN717371

Der Kaninchen Polyklonal Anti-AMFR-Antikörper wurde für WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, AMFR in Proben von Ratte zu detektieren.

Kurzübersicht für AMFR Antikörper (AA 85-180) (ABIN717371)

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-AMFR Antikörper

Bindungsspezifität: AA 85-180

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AMFR/RNF45

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AMFR

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Andere Bezeichnung: RNF45

Hintergrund:

Synonyms: AMF receptor, AMF receptor isoform 1, AMF receptor isoform 2, AMFR, AMFR2_HUMAN, Autocrine motility factor receptor, Autocrine motility factor receptor precursor, isoform 1, Autocrine motility factor receptor precursor, isoform 2, E3 ubiquitin-protein ligase AMFR, gp78, RING finger protein 45, RNF 45, RNF45.

Background: E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR, proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.

Gen-ID: 267

Pathways: ER-Nucleus Signaling