IGF1R Antikörper (pTyr1131, pTyr1146)

Produktnummer ABIN7267901

Der Kaninchen Polyklonal Anti-IGF1R-Antikörper wurde für WB validiert. Er ist geeignet, IGF1R in Proben von Human zu detektieren.

Kurzübersicht für IGF1R Antikörper (pTyr1131, pTyr1146) (ABIN7267901)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IGF1R Antikörper

Bindungsspezifität: pTyr1131, pTyr1146

Verwendungszweck: Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb

Kreuzreaktivität: Human

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Andere Bezeichnung: IGF1R/INSR

Hintergrund: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],INSR/IGF1R,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,IGF1R/INSR

Molekulargewicht: 155kDa

Gen-ID: 3643, 3480

UniProt: P06213, P08069

Pathways: RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie