ABI1 Antikörper (AA 180-230)

Produktnummer ABIN7265359

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ABI1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ABI1 Antikörper (AA 180-230) (ABIN7265359)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ABI1 Antikörper

Bindungsspezifität: AA 180-230

Verwendungszweck: ABI1 Rabbit pAb

Sequenz: PMSGRGTLGR NTPYKTLEPV KPPTVPNDYM TSPARLGSQH SPGRTASLNQ R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-230 of human ABI1 (NP_001012770).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Andere Bezeichnung: ABI1

Hintergrund: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.,ABI1,ABI-1,ABLBP4,E3B1,NAP1BP,SSH3BP,SSH3BP1,Signal Transduction,G protein signaling,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Growth factor,EGF,ABI1

Molekulargewicht: 35-55kDa

Gen-ID: 10006

UniProt: Q8IZP0

Pathways: RTK Signalweg, Response to Water Deprivation, ER-Nucleus Signaling