MAPT Antikörper

Produktnummer ABIN7233074

Der Maus Monoklonal anti-MAPT Antikörper wird verwendet zum Nachweis von MAPT in Proben von Human. Er wurde validiert für WB, ELISA, IF/ICC und DB.

Kurzübersicht für MAPT Antikörper (ABIN7233074)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (fixed cells) (IF/ICC), Dot Blot (DB)

Klon: 1D5

Produktdetails anti-MAPT Antikörper

Verwendungszweck: Anti-Tau Mouse Monoclonal Antibody

Spezifität: This antibody recognizes human, mouse, and rat Tau.

Kreuzreaktivität: Human, Maus, Ratte

Immunogen: Full-length recombinant human Tau441 (2N4R) P301S mutant protein pre-formed fibrils. In humans, mutation P301S gives rise to early-onset dementia.

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at 1-5 μg/mL. A band of ~45.8 kDa is detected.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.09 % sodium azide, 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: This product is stable for at least one (1) year at -20°C.

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT

Hintergrund: Microtubule-associated protein tau,Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {PubMed:21985311, PubMed:32961270}.,Cytoplasm, cytosol, Cell membrane, Cytoplasm, cytoskeleton, Cell projection, axon, Cell projection, dendrite, Secreted,Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size