Tuberin Antikörper (pThr1462)

Produktnummer ABIN7224812

Der Kaninchen Polyklonal anti-Tuberin Antikörper wird verwendet zum Nachweis von Tuberin in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB, IHC und IF.

Kurzübersicht für Tuberin Antikörper (pThr1462) (ABIN7224812)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tuberin Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Tuberin Antikörper

Bindungsspezifität: pThr1462

Verwendungszweck: Rabbit Anti-Tuberin (phospho Thr1462) Polyclonal Antibody

Spezifität: Phospho-Tuberin (T1462) Polyclonal Antibody detects endogenous levels of Tuberin protein only when phosphorylated at T1462.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Tuberin Phospho-Thr1462

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Andere Bezeichnung: Tuberin

Hintergrund: TSC2, TSC4, Tuberin, Tuberous sclerosis 2 proteinMutations in TSC2 (tuberous sclerosis 2) lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 200kD

Gen-ID: 7249

UniProt: P49815

Pathways: RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus