TRAF1 Antikörper (AA 191-240)

Produktnummer ABIN7226868

Der Kaninchen Polyklonal anti-TRAF1 Antikörper wird verwendet zum Nachweis von TRAF1 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für TRAF1 Antikörper (AA 191-240) (ABIN7226868)

Target: TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TRAF1 Antikörper

Bindungsspezifität: AA 191-240

Verwendungszweck: Rabbit Anti-TRAF1 Polyclonal Antibody

Spezifität: TRAF1 Polyclonal Antibody detects endogenous levels of TRAF1.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from TRAF1 at AA range: 191-240

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu TRAF1

Target: TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))

Andere Bezeichnung: TRAF1

Hintergrund: TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6The protein encoded by TRAF1 (TNF receptor associated factor 1) is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins, this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for TRAF1.

Molekulargewicht: 46kD

Gen-ID: 7185

UniProt: Q13077

Pathways: NF-kappaB Signalweg, Apoptose, Cell-Cell Junction Organization, Asymmetric Protein Localization