SPTAN1 Antikörper (Cleaved-Asp1185)

Produktnummer ABIN7212504

Der Kaninchen Polyklonal anti-SPTAN1 Antikörper wird verwendet zum Nachweis von SPTAN1 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für SPTAN1 Antikörper (Cleaved-Asp1185) (ABIN7212504)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SPTAN1 Antikörper

Bindungsspezifität: AA 1110-1190, Cleaved-Asp1185

Verwendungszweck: Cleaved-Spectrin α II (D1185) Polyclonal Antibody

Spezifität: Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Spectrin alpha II at AA range: 1110-1190

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: Spectrin alpha II

Hintergrund: Rabbit Anti-Cleaved-Spectrin α II (D1185) Polyclonal Antibody,SPTAN1, NEAS, SPTA2, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit,Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. Spectrin alpha chain non-erythrocytic 1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in SPTAN1 are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.,Spectrin alpha chain non-erythrocytic 1

Molekulargewicht: observerd band 137kDa

Gen-ID: 6709

UniProt: Q13813

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization