INPP5D Antikörper (AA 1110-1190)

Produktnummer ABIN7217000

Der Kaninchen Polyklonal Anti-INPP5D Antikörper wurde für WB und ELISA validiert. Er ist geeignet, INPP5D in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für INPP5D Antikörper (AA 1110-1190) (ABIN7217000)

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INPP5D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-INPP5D Antikörper

Bindungsspezifität: AA 1110-1190

Verwendungszweck: SHIP-1 Polyclonal Antibody

Spezifität: SHIP-1 Polyclonal Antibody detects endogenous levels of SHIP-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human SHIP-1 at AA range: 1110-1190

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu INPP5D

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Andere Bezeichnung: SHIP-1

Hintergrund: Rabbit Anti-SHIP-1 Polyclonal Antibody,INPP5D, SHIP, SHIP1, Phosphatidylinositol 3, 4,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1,INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.,Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Molekulargewicht: observerd band 133kDa

Gen-ID: 3635

UniProt: Q92835

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling, Warburg Effekt