GCK Antikörper (N-Term)

Produktnummer ABIN7215024

Dieser Anti-GCK-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von GCK in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für GCK Antikörper (N-Term) (ABIN7215024)

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GCK Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GCK Polyclonal Antibody

Spezifität: GCK Polyclonal Antibody detects endogenous levels of GCK protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human GCK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu GCK

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Andere Bezeichnung: GCK

Hintergrund: Rabbit Anti-GCK Polyclonal Antibody,GCK, Glucokinase, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D,Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. Glucokinase localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).,Glucokinase

Molekulargewicht: observerd band 55kDa

Gen-ID: 2645

UniProt: P35557

Pathways: MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process