CARD11 Antikörper (AA 10-90)

Produktnummer ABIN7213938

Dieser Anti-CARD11 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von CARD11 in WB, ELISA, IF und IHC (p). Geeignet für Human und Maus.

Kurzübersicht für CARD11 Antikörper (AA 10-90) (ABIN7213938)

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CARD11 Antikörper

Bindungsspezifität: AA 10-90

Verwendungszweck: CARD 11 Polyclonal Antibody

Spezifität: CARD 11 Polyclonal Antibody detects endogenous levels of CARD 11 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human CARD 11 at AA range: 10-90

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:40000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu CARD11

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Andere Bezeichnung: CARD 11

Hintergrund: Rabbit Anti-CARD 11 Polyclonal Antibody,CARD11, CARMA1, Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1,The protein encoded by CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.,Caspase recruitment domain-containing protein 11

Molekulargewicht: observerd band 130kDa

Gen-ID: 84433

UniProt: Q9BXL7

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, BCR Signaling