ATM Antikörper (pSer1981)

Produktnummer ABIN7226766

Dieser Anti-ATM-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von ATM in WB, ELISA und IHC (p). Geeignet für Human und Maus.

Kurzübersicht für ATM Antikörper (pSer1981) (ABIN7226766)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ATM Antikörper

Bindungsspezifität: pSer1981

Verwendungszweck: Atm (phospho Ser1981) Polyclonal Antibody

Spezifität: Phospho-Atm (S1981) Polyclonal Antibody detects endogenous levels of Atm around the phosphorylation site of S1981 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Atm Phospho-Ser1981

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: Atm

Hintergrund: Rabbit Anti-Atm (phospho Ser1981) Polyclonal Antibody,The protein encoded by ATM (ATM serine/threonine kinase) belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.,Serine-protein kinase ATM

Gen-ID: 472

UniProt: Q13315

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus