IL21 Receptor Antikörper (AA 20-232)

Produktnummer ABIN7193861

Der Maus Monoklonal Anti-IL21 Receptor-Antikörper wurde für ELISA, FACS und ICC validiert. Er ist geeignet, IL21 Receptor in Proben von Human zu detektieren.

Kurzübersicht für IL21 Receptor Antikörper (AA 20-232) (ABIN7193861)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL21 Receptor Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 1C3G9

Produktdetails anti-IL21 Receptor Antikörper

Bindungsspezifität: AA 20-232

Verwendungszweck: CD360 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD360 (AA: 20-232) expressed in HEK293-6e cells supernatant

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/25 - 1/200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: CD360

Hintergrund:

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Molekulargewicht: 59.1 kDa

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg