MCM5 Antikörper

Produktnummer ABIN7181928

Produktdetails anti-MCM5 Antikörper

Target: MCM5 (Minichromosome Maintenance Complex Component 5 (MCM5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human MCM5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MCM5

Target: MCM5 (Minichromosome Maintenance Complex Component 5 (MCM5))

Andere Bezeichnung: MCM5 (MCM5 Produkte)

Hintergrund:

Background: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity By similarity. Interacts with MCMBP.

Robert A. Sclafani, Genetics, May 2002, 161: 47.
Marylynn Snyder, PNAS, Oct 2005, 102: 14539 - 14544.
Christopher J. DaFonseca, PNAS, Mar 2001, 98: 3034.
Cathleen M. Lake, Genetics, Jun 2007, 10.1534

Aliases: CDC 46 antibody, CDC46 antibody, CDC46 homolog antibody, Cell division cycle 46 antibody, DNA replication licensing factor antibody, DNA replication licensing factor MCM 5 antibody, DNA replication licensing factor MCM5 antibody, MCM 5 antibody, MCM5 antibody, MCM5_HUMAN antibody, MGC5315 antibody, Minichromosome maintenance complex component 5 antibody, Minichromosome maintenance deficient (S. cerevisiae) 5 antibody, Minichromosome maintenance deficient 5 antibody, Minichromosome maintenance deficient protein 5 antibody, P1 CDC46 antibody, P1-CDC46 antibody

UniProt: P33992

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA