ATF4 Antikörper (C-Term)

Produktnummer ABIN7180125

Der Kaninchen Polyklonal Anti-ATF4-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, ATF4 in Proben von Human zu detektieren.

Kurzübersicht für ATF4 Antikörper (C-Term) (ABIN7180125)

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ATF4 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human ATF4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ATF4

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Andere Bezeichnung: ATF4

Hintergrund:

Background: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.

Tsujimoto A., J. Virol. 65:1420-1426(1991).
Karpinski B.A., Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992).
Dunham I., Nature 402:489-495(1999).

Aliases: Activating transcription factor 4 antibody, ATF 4 antibody, ATF4 antibody, ATF4 protein antibody, ATF4_HUMAN antibody, cAMP-dependent transcription factor ATF-4 antibody, cAMP-responsive element-binding protein 2 antibody, CREB 2 antibody, CREB-2 antibody, CREB2 antibody, Cyclic AMP dependent transcription factor ATF 4 antibody, Cyclic AMP response element binding protein 2 antibody, Cyclic AMP-dependent transcription factor ATF-4 antibody, Cyclic AMP-responsive element-binding protein 2 antibody, DNA binding protein TAXREB67 antibody, DNA-binding protein TAXREB67 antibody, Tax Responsive Enhancer Element B67 antibody, Tax-responsive enhancer element-binding protein 67 antibody, TaxREB67 antibody, TXREB antibody

UniProt: P18848

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response