SMAD3 Antikörper (Ser204)

Produktnummer ABIN7180084

Dieses Anti-SMAD3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SMAD3 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für SMAD3 Antikörper (Ser204) (ABIN7180084)

Target: SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SMAD3 Antikörper

Bindungsspezifität: Ser204

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Smad3 around the phosphorylation site of serine 204 (A-G-S(p)-P-N).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMAD3

Target: SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))

Andere Bezeichnung: SMAD3

Hintergrund:

Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Zhang Y., Nature 383:168-172(1996).
Riggins G.J., Nat. Genet. 13:347-349(1996).
Arai T., Cancer Lett. 122:157-163(1998).

Aliases: DKFZP586N0721 antibody, DKFZp686J10186 antibody, hMAD 3 antibody, hMAD-3 antibody, hSMAD3 antibody, HSPC193 antibody, HST17436 antibody, JV15 2 antibody, JV15-2 antibody, JV152 antibody, LDS1C antibody, LDS3 antibody, MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody, MAD homolog 3 antibody, Mad homolog JV15 2 antibody, Mad protein homolog antibody, MAD, mothers against decapentaplegic homolog 3 antibody, Mad3 antibody, MADH 3 antibody, MADH3 antibody, MGC60396 antibody, Mothers against decapentaplegic homolog 3 antibody, Mothers against DPP homolog 3 antibody, SMA and MAD related protein 3 antibody, SMAD 3 antibody, SMAD antibody, SMAD family member 3 antibody, SMAD, mothers against DPP homolog 3 antibody, Smad3 antibody, SMAD3_HUMAN antibody

UniProt: P84022

Pathways: Zellzyklus, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagie