NEUROD1 Antikörper (Ser272)

Produktnummer ABIN7180052

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NEUROD1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NEUROD1 Antikörper (Ser272) (ABIN7180052)

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEUROD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NEUROD1 Antikörper

Bindungsspezifität: Ser272

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NEUROD1

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Andere Bezeichnung: NEUROD1

Hintergrund:

Background: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.

Tamimi R., Genomics 34:418-421(1996).
Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).
Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)

Aliases: atonal antibody, basic helix loop helix transcription factor antibody, BETA 2 antibody, Beta cell E box transactivator 2 antibody, BETA2 antibody, BHF 1 antibody, BHF1 antibody, bHLHa3 antibody, class A basic helix loop helix protein 3 antibody, Class A basic helix-loop-helix protein 3 antibody, MODY 6 antibody, MODY6 antibody, NDF1_HUMAN antibody, NeuroD antibody, NeuroD1 antibody, Neurogenic differentiation 1 antibody, Neurogenic differentiation factor 1 antibody, neurogenic helix loop helix protein NEUROD antibody, Neuronal differentiation 1 antibody

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis