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MAPKAP Kinase 2 Antikörper (Ser272)

MAPKAPK2 Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7180045
  • Target Alle MAPKAP Kinase 2 (MAPKAPK2) Antikörper anzeigen
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Bindungsspezifität
    • 39
    • 25
    • 19
    • 16
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser272
    Reaktivität
    • 109
    • 95
    • 95
    • 21
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 133
    • 7
    • 2
    Kaninchen
    Klonalität
    • 119
    • 23
    Polyklonal
    Konjugat
    • 60
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser MAPKAP Kinase 2 Antikörper ist unkonjugiert
    Applikation
    • 90
    • 42
    • 40
    • 39
    • 32
    • 24
    • 19
    • 13
    • 9
    • 8
    • 8
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized non-phosphopeptide derived from Human MAPKAPK2 around the phosphorylation site of serine 272 (A-I-S(p)-P-G).
    Isotyp
    IgG
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    Discover our top product MAPKAPK2 Primärantikörper
  • Applikationshinweise
    WB:1:500-1:3000, IHC:1:50-1:100,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Andere Bezeichnung
    MAPKAPK2 (MAPKAPK2 Produkte)
    Synonyme
    mapkapk2 antikoerper, wu:fb30e10 antikoerper, wu:fc56c10 antikoerper, wu:fi03a01 antikoerper, MGC78852 antikoerper, MAPKAPK2 antikoerper, AA960234 antikoerper, MAPKAP-K2 antikoerper, MK-2 antikoerper, MK2 antikoerper, Rps6kc1 antikoerper, mitogen-activated protein kinase-activated protein kinase 2a antikoerper, mitogen-activated protein kinase-activated protein kinase 2 L homeolog antikoerper, mitogen-activated protein kinase-activated protein kinase 2 antikoerper, MAP kinase-activated protein kinase 2 antikoerper, mapkapk2a antikoerper, mapkapk2.L antikoerper, MAPKAPK2 antikoerper, Mapkapk2 antikoerper
    Hintergrund

    Background: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

    Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124(1994).
    Stokoe D., Biochem. J. 296:843-849(1993).
    Coxon P.Y., Cell. Signal. 15:993-1001(2003).

    Aliases: MAP kinase activated protein Kinase 2 antibody, MAP kinase-activated protein kinase 2 antibody, MAPK activated protein kinase 2 antibody, MAPK-activated protein kinase 2 antibody, MAPK2_HUMAN antibody, MAPKAP K2 antibody, MAPKAP kinase 2 antibody, MAPKAPK 2 antibody, MAPKAPK-2 antibody, MAPKAPK2 antibody, Mitogen activated protein kinase activated protein kinase 2 antibody, MK 2 antibody, MK2 antibody

    UniProt
    P49137
    Pathways
    MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
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