Cyclin D2 Antikörper (Thr280)

Produktnummer ABIN7179999

Der Kaninchen Polyklonal anti-Cyclin D2 Antikörper wird verwendet zum Nachweis von Cyclin D2 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für Cyclin D2 Antikörper (Thr280) (ABIN7179999)

Target: Cyclin D2 (CCND2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Cyclin D2 Antikörper

Bindungsspezifität: Thr280

Verwendungszweck: CCND2 (Ab-280) Antibody

Kreuzreaktivität: Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Cyclin D2

Target: Cyclin D2 (CCND2)

Andere Bezeichnung: CCND2

Hintergrund:

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.

Xiong Y., Genomics 13:575-584(1992).
Palmero I., Oncogene 8:1049-1054(1993).
Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody

UniProt: P30279

Pathways: Zellzyklus, Mitotic G1-G1/S Phases