CSF1R Antikörper (Tyr809)

Produktnummer ABIN7179996

Der Kaninchen Polyklonal Anti-CSF1R-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, CSF1R in Proben von Human zu detektieren.

Kurzübersicht für CSF1R Antikörper (Tyr809) (ABIN7179996)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-CSF1R Antikörper

Bindungsspezifität: Tyr809

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human CSFR around the phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Andere Bezeichnung: CSF1R

Hintergrund:

Background: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

Hampe A., Oncogene Res. 4:9-17(1989).
Coussens L., Nature 320:277-280(1986).
Andre C., Genomics 39:216-226(1997)

Aliases: C FMS antibody, CD 115 antibody, CD115 antibody, CD115 antigen antibody, CFMS antibody, Colony stimulating factor 1 receptor antibody, Colony stimulating factor I receptor antibody, CSF 1 R antibody, CSF 1R antibody, CSF-1 receptor antibody, CSF-1-R antibody, CSF1 R antibody, CSF1R antibody, CSF1R_HUMAN antibody, CSFR antibody, EC 2.7.10.1 antibody, FIM 2 antibody, FIM2 antibody, FMS antibody, FMS proto oncogene antibody, FMS protooncogene antibody, HDLS antibody, M-CSF Receptor antibody, M-CSF-R antibody, Macrophage colony stimulating factor 1 receptor antibody, Macrophage colony stimulating factor I receptor antibody, Macrophage colony-stimulating factor 1 receptor antibody, McDonough feline sarcoma viral (v fms) oncogene homolog antibody, MCSFR antibody, Oncogen FMS antibody, Proto-oncogene c-Fms antibody, V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody

UniProt: P07333

Pathways: RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization