TAL1 Antikörper (AA 1-324) (Biotin)

Produktnummer ABIN7179879

Der Kaninchen Polyklonal Anti-TAL1-Antikörper wurde für ELISA validiert. Er ist geeignet, TAL1 in Proben von Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für TAL1 Antikörper (AA 1-324) (Biotin) (ABIN7179879)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAL1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-TAL1 Antikörper (Biotin)

Bindungsspezifität: AA 1-324

Kreuzreaktivität: Zebrafisch (Danio rerio)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Andere Bezeichnung: tal1

Hintergrund:

Background: Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.

Aliases: tal1 antibody, scl antibody, tal-1 antibody, si:ch211-135j1.3 antibody, T-cell acute lymphocytic leukemia protein 1 homolog antibody, TAL-1 antibody, Stem cell protein antibody, zSCL antibody

UniProt: O93507

Pathways: Stem Cell Maintenance