P4HB Antikörper (AA 20-509) (Biotin)

Produktnummer ABIN7177783

Dieses Anti-P4HB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von P4HB in ELISA. Geeignet für Maus.

Kurzübersicht für P4HB Antikörper (AA 20-509) (Biotin) (ABIN7177783)

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P4HB Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-P4HB Antikörper (Biotin)

Bindungsspezifität: AA 20-509

Kreuzreaktivität: Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Mouse Protein disulfide-isomerase protein (20-509AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Andere Bezeichnung: P4hb

Hintergrund:

Background: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP

Aliases: P4hb antibody, Pdia1Protein disulfide-isomerase antibody, PDI antibody, EC 5.3.4.1 antibody, Cellular thyroid hormone-binding protein antibody, Endoplasmic reticulum resident protein 59 antibody, ER protein 59 antibody, ERp59 antibody, Prolyl 4-hydroxylase subunit beta antibody, p55 antibody

UniProt: P09103

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism