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IRF3 Antikörper (AA 1-419) (HRP)

IRF3 Reaktivität: Maus ELISA Wirt: Kaninchen Polyclonal HRP

Produktnummer ABIN7177340

Datenblatt (PDF)

Target Alle IRF3 Antikörper anzeigen

IRF3 (Interferon Regulatory Factor 3 (IRF3))
Bindungsspezifität
15

15

14

13

10

6

5

4

4

4

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-419
Reaktivität
141

81

54

31

18

3

2

2

2

1

1

1

1
Maus
Wirt
133

22

2
Kaninchen
Passende Sekundärantikörper
Klonalität
119

38
Polyklonal
Konjugat
93

9

7

5

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1
Dieser IRF3 Antikörper ist konjugiert mit HRP
Applikation
120

64

37

35

29

27

21

13

13

13

6

4

3

2

1

1

1

1
ELISA

Kreuzreaktivität

Maus

Aufreinigung

>95%, Protein G purified

Immunogen

Recombinant Mouse Interferon regulatory factor 3 protein (1-419AA)

Isotyp

IgG

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anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibody
IRF3 Reaktivität: Human WB, IHC, IF, ChIP Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 Reaktivität: Human WB, ELISA, IF, IP Wirt: Maus Monoclonal 3C8 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibody
IRF3 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibody
IRF3 Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibody
IRF3 Reaktivität: Human, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibody
IRF3 Reaktivität: Human WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1268-1341) antibody
IRF3 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer385) antibody
IRF3 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target

IRF3 (Interferon Regulatory Factor 3 (IRF3))

Andere Bezeichnung

Irf3 (IRF3 Produkte)

Hintergrund

Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Aliases: Irf3 antibody, Interferon regulatory factor 3 antibody, IRF-3 antibody

UniProt

P70671

Pathways

TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades