TRIM24 Antikörper (AA 891-1012) (HRP)

Produktnummer ABIN7172711

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRIM24 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TRIM24 Antikörper (AA 891-1012) (HRP) (ABIN7172711)

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM24 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-TRIM24 Antikörper (HRP)

Bindungsspezifität: AA 891-1012

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Transcription intermediary factor 1-alpha protein (891-1012AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Andere Bezeichnung: TRIM24

Hintergrund:

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at \\\'Lys-4\\\' (H3K4me0) and acetylated at \\\'Lys-23\\\' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Aliases: E3 ubiquitin protein ligase TRIM24 antibody, E3 ubiquitin-protein ligase Trim24 antibody, hTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 alpha antibody, TIF1 antibody, TIF1-alpha antibody, TIF1A antibody, TIF1A_HUMAN antibody, TIF1ALPHA antibody, Transcription intermediary factor 1-alpha antibody, Transcriptional intermediary factor 1 alpha antibody, Transcriptional intermediary factor 1 antibody, Trim24 antibody, Tripartite motif containing 24 antibody, Tripartite motif-containing protein 24 antibody

UniProt: O15164