TRIM24 Antikörper (C-Term)

Produktnummer ABIN7180275

Produktdetails anti-TRIM24 Antikörper

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human TRIM24.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Andere Bezeichnung: TRIM24 (TRIM24 Produkte)

Synonyme: TRIM24 antikoerper, PTC6 antikoerper, RNF82 antikoerper, TF1A antikoerper, TIF1 antikoerper, TIF1A antikoerper, TIF1ALPHA antikoerper, hTIF1 antikoerper, ptc6 antikoerper, rnf82 antikoerper, tf1a antikoerper, tif1 antikoerper, tif1a antikoerper, tif1alpha antikoerper, A130082H20Rik antikoerper, AI447469 antikoerper, D430004I05Rik antikoerper, TIF1-alpha antikoerper, TIF1alpha antikoerper, Tif1a antikoerper, tripartite motif containing 24 antikoerper, transcription intermediary factor 1-alpha antikoerper, tripartite motif containing 24 S homeolog antikoerper, tripartite motif-containing 24 antikoerper, TRIM24 antikoerper, trim24 antikoerper, LOC100548578 antikoerper, trim24.S antikoerper, Trim24 antikoerper

Hintergrund:

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes By similarity.

Thenot S., J. Biol. Chem. 272:12062-12068(1997).
Venturini L., Oncogene 18:1209-1217(1999).
Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).

Aliases: E3 ubiquitin protein ligase TRIM24 antibody, E3 ubiquitin-protein ligase Trim24 antibody, hTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 alpha antibody, TIF1 antibody, TIF1-alpha antibody, TIF1A antibody, TIF1A_HUMAN antibody, TIF1ALPHA antibody, Transcription intermediary factor 1-alpha antibody, Transcriptional intermediary factor 1 alpha antibody, Transcriptional intermediary factor 1 antibody, Trim24 antibody, Tripartite motif containing 24 antibody, Tripartite motif-containing protein 24 antibody

UniProt: O15164