TRIM24 Antikörper (C-Term)

Produktnummer ABIN6265731

Produktdetails anti-TRIM24 Antikörper

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TRIM24 Antibody detects endogenous levels of total TRIM24.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIM24, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Andere Bezeichnung: TRIM24 (TRIM24 Produkte)

Synonyme: TRIM24 antikoerper, PTC6 antikoerper, RNF82 antikoerper, TF1A antikoerper, TIF1 antikoerper, TIF1A antikoerper, TIF1ALPHA antikoerper, hTIF1 antikoerper, ptc6 antikoerper, rnf82 antikoerper, tf1a antikoerper, tif1 antikoerper, tif1a antikoerper, tif1alpha antikoerper, A130082H20Rik antikoerper, AI447469 antikoerper, D430004I05Rik antikoerper, TIF1-alpha antikoerper, TIF1alpha antikoerper, Tif1a antikoerper, tripartite motif containing 24 antikoerper, transcription intermediary factor 1-alpha antikoerper, tripartite motif containing 24 S homeolog antikoerper, tripartite motif-containing 24 antikoerper, TRIM24 antikoerper, trim24 antikoerper, LOC100548578 antikoerper, trim24.S antikoerper, Trim24 antikoerper

Hintergrund:

Description: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Gene: TRIM24

Molekulargewicht: 117kDa

Gen-ID: 8805

UniProt: O15164