SOCS1 Antikörper (AA 1-211) (HRP)

Produktnummer ABIN7170994

Dieses Anti-SOCS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SOCS1 in ELISA. Geeignet für Human.

Kurzübersicht für SOCS1 Antikörper (AA 1-211) (HRP) (ABIN7170994)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-SOCS1 Antikörper (HRP)

Bindungsspezifität: AA 1-211

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1

Hintergrund:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Aliases: CISH 1 antibody, CISH1 antibody, Cytokine inducible SH2 protein 1 antibody, JAB antibody, JAK binding protein antibody, JAK-binding protein antibody, Janus kinase binding protein antibody, SOCS 1 antibody, SOCS-1 antibody, Socs1 antibody, SOCS1_HUMAN antibody, SSI 1 antibody, SSI-1 antibody, SSI1 antibody, STAT induced STAT inhibitor 1 antibody, STAT-induced STAT inhibitor 1 antibody, Suppressor of cytokine signaling 1 antibody, Supressor of cytokine signalling 1 antibody, TEC interacting protein 3 antibody, Tec-interacting protein 3 antibody, TIP 3 antibody, TIP-3 antibody, TIP3 antibody

UniProt: O15524

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus